Control of the B Cell Immune Response and Lymphoproliferations (CRIBL)
UMR CNRS 7276

Contact

Michel Cogne – Director
(0033) 519 56 42 00

Adress : Faculté de Médecine Centre de Biologie et de Recherche en Santé (CBRS) – 2 rue du Dr Marcland – 87025 LIMOGES CEDEX

Administrative Supervision : Université de Limoges – CNRS

Parent Institute : GEIST
Doctoral School : ED 524 – Bio-Santé

> Website

Presentation

The scientific projects of the team are developed handin-hand with national and international bodies (in particular with the Cancéropôle Grand Sud-Ouest (Greater South-West Cancer Centre and European networks). The team implements cutting-edge molecular and cell biology methods (in particular transgenesis and homologous recombination) for three types of research objectives :

• Fundamental : molecular mechanisms that regulate antibody production / study of genetic remodeling associated with the differentiation and maturation of immunity cells and more particularly B lymphocyte / biology of B lymphomagenesis B and tumour transformation /physiology of the normal B lymphocyte, etc.

• In relation to experimental medicine issues : development of mechanistic models for studying immunopathological or onco-hematological disorders / participation in clinical research / involvement with the National Reference Centre on amyloidosis and immunoglobulin deposition diseases / implementation of new diagnostic tools for lymphomas;

• Finalized : approaches that are specifically related to improving the diagnosis and treatment of tumoral (in particular hematological) and dysimmune pathologies / technological developments that focus on flow cytometry methods. This array of theme variations, which focuses mainly on the B lymphocyte, provides mutual benefit in the different research areas. Studying pathological mechanisms and possible therapeutic applications simultaneously promotes fundamental research and can occasionally guide it. The location within the medical cluster privileges interactions and complementarity between fundamental and clinical research.

Research themes

Physiology and Genetics of B lymphocyte ; Lymphomagenesis Mechanism ; Immunoglobulin Deposition Diseases ; Therapeutic Antibodies

Keywords

Molecular Biology ; Cell Biology ; Genome ; Genetics ; Transgenesis ; Oncogenesis ; Hematology ; Immunology ; Animal Models ; Lymphoproliferations

Honours

Michel Cogné : senior member of the IUF, Laureate of the French Academy of Medicine

Equipment / Technical resources

Confocal laser scanning microscope, Transgenesis, Microinjection, Real-time quantitative and classical PCR /Flow cytometry / Rapid cell sorting, 3D flow imager/cytometry Cell culture rooms

Partnerships

Active National University Partnerships : UMR8126-CNRS IGR Villejuif / INSERM Montpellier (B. Klein) /INSERM U563, Purpan, Toulouse (P. Brousset) / Inserm Bichat, Paris (R. Monteiro) / IGBMC Strasbourg (B. Reina-San-Martin) / INSERM Paris Diderot (C. Francastel)/INSERM Pitié-Salpêtrière Paris (F. Davi)
Current International University Partnerships : Pr. F.W. Alt (Boston) / Dr. B. Cortesy (Lausanne) / Dr. A. Kenter (Chicago) / Pr. G. Bornkamm (Munich) / Dr. O. Dewuyst, (Bruxelles) / Dr. M. Van Egmond (Amsterdam) CNB-CSIC Madrid Spain
National Industrial Partnerships : CAYLA-Invivogen (Toulouse,-San Diego) /LFB (Lille) /) / Dendritics (Lyon) / B Cell Design (Limoges) International Industrial Partnerships : Beckman-Coulter, Fullerton, USA, Amnis corporation, (Seattle, USA)

Industrial applications

3D fluorescence microscopy, KO/KI transgenic mice models, PCR Genotyping and southern blot, Real-time quantitative and classical PCR, Classical and 3D analysis using flow cytometry, Rapid cell sorting using flow cytometry, Cell culture: ES and lymphoid cell lines, Recombinant antibodies