Cellular Homeostasis and Diseases (HCP)
EA 3842


Contact

Jauberteau Marie-Odile – Director
(0033) 555 43 58 68

Adress : Homéostasie Cellulaire et Pathologies Faculté de Médecine 2 rue du Docteur Marcland 87025 LIMOGES CEDEX

Administrative Supervision : Université de Limoges

Parent Institute : GEIST

Doctoral School : ED 524 Bio-Santé

Associated Research Masters : Master 1-2 Génétique et physiologie Limoges Master 2 Ingénierie et bio-santé Poitiers Master 2 Cancérologie, Paris Sud

Key figures (31/12/2014)

Professors : 20
Other researchers  : 7
Accreditated to direct research (HDR) : 16
Doctoral Students : 12
Engineers, Technicians : 2

Scientific Publication (2011-2014)

Peer reviewed journal : 110
Thesis defended : 13
Book chapters  : 4
Conference presentations : 7
Other : 4

> Website publication

Economic Added Value (2011-2014)

Number of patents filed : 3 dont 2 en copropriété
Number of industrial or research agreements with major organizations : 2
Start-up created as a result of research activities since 2005 : 1
National conferences, seminars organized : 1
Competitiveness clusters with which the laboratory is associated : 3

Presentation

The team project focuses on cell survival depending on neuropeptides in oncology. The project is developed over 4 complementary themes :

  1. Endogenous secretion of neuropeptides and interaction of their signaling pathways involved in cell survival
  2. Autophagic activation linked to the interaction with neurotrophins
  3. Involvement of neurotrophins in therapeutic resistance due to cancer stem cells
  4. Functions of exosomes in tumor microenvironment associated to mechanisms of therapeutic escape

These different topics are achieved by developing translational and transdisciplinary research in order to :

  • Identify and evaluate the value of diagnostic and prognostic biomarkers 
  • To contribute in the development of new tools for diagnosis in collaboration with labex Σ-Lim teams.

Research themes

Neuropeptides and Tumor Cell Survival : – Endogenous secretion and cell signaling – Autophagy and neurotrophins – Cancer stem cells – Exosomes and tumor microenvironment

Keywords

Oncology ; Neuropeptides ; Neurotrophins ; exosomes ; Cancer Stem Cells ; Autophagy ; Biomarkers

Equipment / Technical resources

Fluorescence linear and inverted microscopes ; Fluorescence binocular loupe ; Immunochemistry automatic device ; Ultracentrifuge ; Classical and Real time PCR ; Chemi-luminescent detection system for western-blotting analysis G-Box ; Colorimetric and fluorescence microplate readers ; In vitro electroporator ; Cell sorting equipment (SdFFF: sedimentation field flow fractionation) ; Stereotaxy equipments ; Experimental tumour model on chorioallantoic membrane (CAM) ; Lentivirus transfection and crispR-Cas9 system ; Isolation and analysis of exosomes ; Animal facilities ; Access to technical plateforms : flow cytometry with cell sorting, confocal microscopy, Sequencing and transcriptomic analysis

Partnerships

Active National University Partnerships : Poitiers : UMR CNRS 6187, EA 4331 and EA 3805 ; Strasbourg: UMR CNRS 7200, Therapeutic Innovation Laboratory ; Bordeaux : UMR CNRS 5095, IBCG, Neuro-oncology network from Cancéropôle, Grand Sud-Ouest (Greater South-West Cancer Centre) ; Limoges : UMR INRA 1061, UMR CNRS 7276  Department of Waves and Associated Systems, UMR CNRS 7252 Current International University Partnerships : University of Castilla de la Mancha, Albacete) : Pr Ricardo Sanchez-Prieto, Liverpool university : Pr Michael Clague, Pr John Field
National Industrial Partnerships : iDD-biotech (Dardilly) ; Neuronax (Clermont-Ferrand) ; Roche (Bale) ; ALAIR-AVD (Haute-Vienne) ; Oncomedics ; Kamax

Industrial applications

Development of diagnostic tools ; Knowledge transfer and promotion activities