About me...
H-index: 18 (Web Of Science)
ORCID: 0000-0001-5846-8616
Striking Achievements
- SK3 gene Polymorphism is associated with Taxane Neurotoxicity and Cell Calcium Homeostasis, Clin. Cancer. Res., doi: 10.1158/1078-0432.CCR-18-0870
- Endogenous Metabolites-Mediated Communication Between OAT1/OAT3 and OATP1B1 May Explain the Association Between SLCO1B1 SNPs and Methotrexate Toxicity, Clin. Pharmacol. Ther., 104 (2018), 687-698
- Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions, Biochem. Pharmacol., 140 (2017),, 124-138
- Endogenous metabolites that are substrates of organic anion transporter’s (OATs) predict methotrexate clearance, Pharmacol. Res., 118 (2017), 121-32
- Urinary coproporphyrin I/(I + III) ratio as a surrogate for MRP2 or other transporter activities involved in methotrexate clearance, Br. J. Clin. Pharmacol., 78 (2014), 329-342
- Since 2008: Associate Professor of Pharmacology (MCU-PH), Faculty of Medicine of Tours and Dpt Biochemistry, University Hospital of Tours
- Since 2008: Head of the pharmacogenetics unit
- Since 2001: Associate Professor of Pharmacology (MCU-PH), Faculty of Medicine of Tours and Dpt Pharmacology-toxicology, University Hospital of Tours
- 1997-2000: Associate Professor of Pharmacology, Faculty of Medicine of Tours and Dpt Pharmacology-toxicology University, Hospital of Tourss
- 1995-1996: Associated Hospital practionner, Dpt Pharmacology-toxicology, University Hospital of Tours
- 1992-1994: Hospital Assistant, Dpt Pharmacokinetics, University Hospital of Marseille
- 1988-1992: Pharmacist Resident, University Hospital of Marseille
European Consortia
- 2009-2015: Associated scientist in the FP7 “TINN” European consortium
French Network
- Member of the board of the French Network of Pharmacogenetics (RNPGx)
- Participated in 3 national consensus papers about pharmacogenetics tests
- 1991 Master degree, Université Aix-Marseille 2, France
- 1992 PharmD degree, Faculty of Pharmacy, Marseille, France
- 1992 Diploma of Specialization in clinical pharmacology (DES-PIBM), Faculty of Pharmacy, Marseille, France
- 1995 PhD degree, Université Aix-Marseille 2, France
- 2003 HDR (habilitation to mentor PhD students), Université de Tours
Supervision
- – Supervision or co-supervision of 6 PhD theses and 12 master degree students
Teaching
- Basic and clinical pharmacology teaching at Faculty of Medicine, University of Tours
- Management of a teaching unit focusing on Personalized medicine
- Since 2006: Member of the National University Council (CNU 48-03) of Pharmacology
- Since 2008: Responsible of the pharmacogenetics unit of the Dpt of Biochemistry, University hospital of Tours, France
- Since 2011: Treasurer of the French Society of Pharmacology and Therapeutics (SFPT)
- 2011-2014: Head of the “Paediatric Investigation Plans” group of the French drug authority agency (ANSM)
RESEARCH ACTIVITIES
Since 2017:
- Evaluation of membrane transporters as sources of pharmacokinetic variability using metabolomics approaches, University of Limoges, U1248, IPPRITT
2007-2016:
- Evaluation of transporters as sources of pharmacokinetic variability, EA4245, University of Tours
2000-2006:
- Pharmacokinetic variability of immunosuppressant drugs and monoclonal antibodies, EA3853, University of Tours
1996-2000:
- Pharmacokinetic variability of paediatric drugs, University of Tours
