About me...
H-index: 21
ORCID: 0000-0001-8460-903X
ResearcherID: O-2410-2014
Striking Achievements
- Pharmacogenetics-based personalized therapy: Levels of evidence and recommendations from the French Network of Pharmacogenetics, Therapie, (RNPGx), 72 (2017), 185-192
- Multidrug resistance-associated protein 4 (MRP4) controls ganciclovir intracellular accumulation and contributes to ganciclovir-induced neutropenia in renal transplant patients, Pharmacol. Res., 111 (2016), 501-508
- A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation, Pharmacogenomics, 17 (2016), 375-391
- Pharmacogenetic Biomarkers Predictive of the Pharmacokinetics and Pharmacodynamics of Immunosuppressive Drugs, Ther. Drug. Monit., 38 (2016), S57-S69
- The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics, Clin. Pharmacol. Ther., 87 (2010), 100-108
- Since 2014: Full Professor of pharmacology, Faculty of Pharmacy, Limoges.Head of the teaching department of Pharmacology (2 associate prof., 1 study engineer, 1 post-doc) & Hospital Pharmacologist, department of Pharmacology, Toxicology & Pharmacovigilance, Limoges
- 2006-2014: Associate Professor in medical pharmacology, Faculty of Medicine, Limoges & Hospital Pharmacologist, department of Pharmacology, Toxicology & Pharmacovigilance, Limoges
- 2005-2006: Hospital pharmacologist, department of Pharmacology and Toxicology, University Hospital of Limoges
Awards
- 2013-2016: Recipient of the “Prime d’Excellence Scientifique” (PES; personal grant for scientific excellence)
Others
- Vice-Chair of the IATDMCT pharmacogenetics comitee (International Association of Therapeutic Drug Monitoring & Clinical Toxicology
- Board member of the French Network for Pharmacogenetics (“RNPGx”) (since 2014)
- Editorial board member of the Therapeutic Drug Monitoring and Thérapie Journals
- 2012 & 2014 Professional mobility (6 months) – Department of pharmacokinetics and toxicology (Prof. Bruno Lacarelle) Assistance Publique-Hopitaux de Marseille (AP-HM), Timone Hospital, Marseille, France
- 2010 French accreditation to supervise research (“Habilitation à Diriger des Recherches”, HDR) Defended on June 16th, 2010 – University of Limoges
- 2008 Post-doctoral fellow (6 months) – Center for Pharmacogenomics (Prof. Kathleen M Giacomini)
University of California, San Francisco (UCSF), USA - 2005 Ph.D. degree in pharmacology – Laboratory of medical pharmacology (Prof. Pierre Marquet) Faculty of Medicine, University of Limoges, France. Defended on October 19th, 2005
- 2002 Research master degree in experimental and clinical pharmacology – “Diplôme d’Etude Approfondie” (DEA) Faculty of Medicine, University of Paris XI, Paris, France.
- 2002 Doctor of Pharmacy, Faculty of Pharmacy, University of Limoges, France
- 2001 Master of Biological and Medical Sciences, Faculty of Medicine and Pharmacy, Limoges
Supervision
- Head of a pharmacogenomics group in the research unit 1248 (director Prof. Pierre Marquet) jointly supported by Inserm (National Institute on Health and Medical Research) and the University of Limoges with a strong partnership with the University Hospital of Limoges, France
- Supervisor or co-supervisor of 9 PhD students (since 2007) and 13 research master students (since 2005)
Teaching – Head of the teaching department of Pharmacology
- Pharmaceutical students (2nd, 3rd, 4th and 5th years of study):
- System pharmacology (nervous system and cardiovascular; inflammation & immune systems, metabolic diseases)
- Applied pharmacology (drug-drug interactions, prescription analyses, case studies)
- Pharmacology in drug discovery and development (Regulatory agencies expectations, case studies)
- Community pharmacists and residents in medicine or pharmacy:
- Applied pharmacology (drug-drug interactions, pharmacogenetics, case studies)
- Research masters and post-university courses (Limoges, Paris, Clermont-Ferrand, Tours):
- Pharmacogenetics
- Personalized medicine in transplantation
- Pharmacology in drug discovery and development
RESEARCH ACTIVITIES
Main research interests
- Pharmacogenetics of immunosuppressants and other treatments in transplantation
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Implementation of Pharmacogenetics in clinical routine
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Drugs and xenobiotics disposition in humans
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Pharmacoepigenetics
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Next-Generation Sequencing
Experience and Skills
- Pharmacogenetics: experience includes real time PCR, High Resolution Melting and direct sequencing. IT skills include the design of assay, sequence analysis and haplotype analysis. Clinical association studies and experimental pharmacogenetics.
- Drug metabolism and transport studies: Experience includes preparation and use of in vitro models (microsomes, recombinant enzymes), design of methods and strategies for identification of metabolites, enzyme, or isoforms involved in a metabolic pathway (either of phase I or phase II), enzyme kinetics, in vitro-in vivo extrapolation and drug-drug interaction studies. Transport studies using caco2, HepaRG. Molecular cloning and cell transfection.
- Mass spectrometry applied to structural elucidation and determination of small molecules.
