Laboratory of Chemistry of Natural Substances (LCSN)
EA 1069

The LCSN is an original multidisciplinary structure devoted to developing therapeutically and phytosanitary-active molecules and to valorizing biomass. The first line of research aims to develop biomolecules (Photosensitizers and polyphenols) for therapeutic applications in particular cancer. For example, we synthesize photosensitizers (porphyrins or chlorins) suitable to specifically destroy, under the action of light, either tumors or bacteria. One of the important themes of this axis is to vectorize specific ways these active molecules (photosensibilsateurs or polyphenols) to the diseased (cancerous) cells without affecting the healthy tissues. We develop new agents vectorisations as polyamines or specific peptide sequences but also nanoobjects such as cellulose nanocrystals or gold nanoparticles. Biological tests in vitro and in vivo have demonstrated the activity of a considerable number of these compounds on cancer cells and on pathogenic bacteria. The second research area is aimed at valorizing biomass by modifying agricultural and forestry by-products (cereal brans, straw, corn cobs, bark and sawdust). Plastics have been produced from these raw materials. With bark, we have made micropollutant filters to trap heavy metals contained in water. This work is associated with studies on the role of glycosylation in the response of trees to environmental stress and is linked to a phytoremediation program that, in particular, analyses the in-vivo influence of metals on plant carbohydrates. Finally, the LCSN has initiated a program that aims, firstly, to degrade or modify plant polysaccharides via an enzyme action to obtain antibiotic, anticancer or anti-allergy molecules and, secondly, to study carbohydrate and proteic determinants involved in probiotic activity of bacteria. The processes for manufacturing new products use “green chemistry” methods. The laboratory has the indispensable analytical and biological testing means for carrying out groundbreaking research. The LCSN has developed key relationships with institutional and industrial organizations. The valuation of the laboratory’s research activities have allowed the creation of five start-ups.

Organic Synthesis ;  Organic Chemistry ; Therapeutic Chemistry ; Green Chemistry ; Plant Chemistry ; Biological evaluation ; Probiotics and Prebiotic ; Oligosaccharides ; Wood Xylogenesis ; Polyphenols

Bio-Organic Chemistry ; Natural-Product ; Chemistry ; Carbohydrates ; Porphyrins ; Cellulose ; Wood ; Polyphenols ; Natural Resources ; Polysaccharides

Spectroscopy (IR,IR Microscopy, RAMAN Microscopy UV-vis, NMR, mass, absorption atomic, fluorescence, nanoziser, EPR, etc.) Chromatography (HPLC, GC/MS, LC/MS, combiflash, etc.) / ultracentrifugation / UF and reverse osmosis Mono and two-dimensional electrophoresis CO2 incubator Cell culture material, Microwave , lyophilistor

Biomass Valorization ; Cosmetics ; Pharmaceuticals and Food Supplements Biofertilizer

Organic chemistry, Agrochemistry, Agroressource, Environment, Pharmaceutical, Cosmetics, health

Active National University Partnerships : Universities of Rouen, Bordeaux, Paris-6, Paris 11, Poitiers, Montpellier, Béthune, Nantes (INRA), (UAGPF-INRA), Clermont Ferrand (PIAF), Nancy, Reims, CNAM de Paris, Limoges (ENSCI), Poitiers, La Rochelle, Toulouse Current International University Partnerships : Cluj (Romania), Taïchung (Taiwan), Trois Rivières (Canada), Kenitra (Morocco), Monastir (Tunisia), Hull (Great Britain), Neuchatel (Suisse), Dublin (Ireland) Louvain la Neuve (Belgique), BLIDA (Algérie), Marrakech (Marocco) National Industrial Partnerships  : L’OREAL, SILAB, SOTHYS, ID BIO, Pe@rl, AREVA, Lafarge, SANOFI-SYNTHELABO